E-MTAB-1303 - Transcription profiling by array of Cre recombinase mediated deletion of Id1, Id2 and Id3 in a temporally controlled fashion in tumor cells of Id1, Id2, Id3 floxed mice
Submitted on 9 July 2012, released on 30 April 2013, last updated on 3 May 2014
The experiment was designed to achieve Cre recombinase mediated deletion of Id1, Id2 and Id3 in a temporally controlled fashion in tumor cells of Id1, Id2, Id3 floxed mice with the aim of comparing the gene expression profiles of Id expressing versus Id deleted tumors.
transcription profiling by array, genetic modification design, in vivo
The Id-RAP1 axis is essential for glioma maintenance and residency of glioma cells in the perivascular niche. Niola F, Zhao X, Singh D, Sullivan R, Castano A, Verrico A, Zoppoli P, Morvinski D, Sulman E, Barrett L, Zhuang Y, Verma I, Benezra R, Aldape K, Iavarone A, Lasorella A.