E-MTAB-1192 - Transcription profiling by array of mouse wild-type and Insulin receptor (InsR)/Igf1 receptor (Igf1R) double knockout mutant Sertoli cells from testis at embryonic day E17.5 and Postnatal day 5
Last updated on 29 October 2012, released on 9 March 2013
we performed the analysis of SOX9-GFP+ cells purified from mouse embryonic testis at embryonic day E17.5 and Postnatal day 5 and analyzed the effect of the deletion of the Insulin receptor (InsR) and Igf1 receptor (Igf1R) by comparing double mutant and control SOX9+ Sertoli cells
transcription profiling by array, genetic modification
An essential role for insulin and IGF1 receptors in regulating Sertoli cells proliferation, testis size and FSH action in mice. Jean-Luc Pitetti*, Pierre Calvel*, Marilena D. Papaioannou*, Florence Aubry?, Christopher Cederroth*, Fran?oise Urner3, Betty Fumel?, Michel Crausaz3, Pedro Luis Herrera*, Fran?ois Pralong2, Marc Germond3, Florian Guillou?, Bernard J?gou? and Serge Nef*??.