E-MTAB-1065 - Transcription profiling by array of clinical samples of carcinoma tissues compared to paired normal mucosae.

Status
Released on 2 November 2013, last updated on 3 May 2014
Organism
Homo sapiens
Samples (48)
Array (1)
Protocols (7)
Description
We model processes of wound healing and tumor growth, by studying the effects of normal and cancer epithelial cells on normal fibroblasts and their reciprocal effect on normal keratinocytes in vitro. We find strong parallels between the two processes and compare our observations with transcriptional analysis of 24 clinical samples of squamous cell carcinoma. This dataset contains the clinical samples, for tissue culture samples, see E-MTAB-1064. Clinical samples of carcinoma tissues were compared to paired normal mucosae.
Experiment types
transcription profiling by array, co-expression, disease state, in vivo
Contacts
Barbora Dvorankova, Cestmir Vlcek, Hana Kovarova, Hans-Joachim Gabius, Hynek Strnad <strnad@img.cas.cz>, Jan Betka, Jan Motlik, Jan Paces, Jan Plzak, Karel Smetana, Jr <karel.smetana@lf1.cuni.cz>, Karla Jarkovska, Lukas Lacina, Martin Chovanec, Michal Kolar <kolarmi@img.cas.cz>, Pavol Szabo, Zdenek Cada, Zdenek Fik
Citation
Upregulation of IL-6, IL-8 and CXCL-1 production in dermal fibroblasts by normal/malignant epithelial cells in vitro: Immunohistochemical and transcriptomic analyses. Kolář M, Szabo P, Dvořánková B, Lacina L, Gabius HJ, Strnad H, Sáchová J, Vlček C, Plzák J, Chovanec M, Cada Z, Betka J, Fík Z, Pačes J, Kovářová H, Motlík J, Jarkovská K, Smetana K Jr . Biology of the Cell 104(12):738-751 (2012), Europe PMC 23043537
MIAME
PlatformsProtocolsFactorsProcessedRaw
Files
Investigation descriptionE-MTAB-1065.idf.txt
Sample and data relationshipE-MTAB-1065.sdrf.txt
Raw data (1)E-MTAB-1065.raw.1.zip
Processed data (1)E-MTAB-1065.processed.1.zip
Array designA-MEXP-1173.adf.txt
Links