E-MTAB-1019 - Transcription profiling by array of liver from C57BL6 mice transfected with AAV8 vectors expressing either GFP or human macrophage inhibitory factor (MIF) or none (PBS)

Status
Released on 7 March 2013, last updated on 3 June 2014
Organism
Mus musculus
Samples (16)
Array (1)
Protocols (5)
Description
MIF is a general mediator of inflammatory responses and is associated with several inflammatory diseases including atherosclerosis. Therefore MIF is currently investigated as a therapeutic target for atherosclerosis. Generation of AAV8 vectors expressing human MIF was initiated to overexpress human MIF in AAV8 target tissues (liver, heart, muscles) of C57/Bl6 to study biological function of MIF in vivo and to provide an animal model for testing of MIF antibodies. Aim of the gene expression profiling experiment: Livers of AAV8-CMV-MIF treated animals in order to identify established and potential novel target genes of MIF induced signalling
Experiment types
transcription profiling by array, co-expression, in vivo
Contact
Citation
Macrophage migration inhibitor factor is regulated in a peritonitis model but overexpression does not augment inflammation response. Andre Broermann, Annika Baur, Peter Maier, Norbert Redemann, Gerd Luippold, Tobias Hildebrandt, Eric Simon, Sebastian Kreuz, Jörg F. Rippmann.
MIAME
PlatformsProtocolsVariablesProcessedRaw
Files
Investigation descriptionE-MTAB-1019.idf.txt
Sample and data relationshipE-MTAB-1019.sdrf.txt
Raw data (1)E-MTAB-1019.raw.1.zip
Array designA-MEXP-1174.adf.txt
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