E-MEXP-948 - Transcription profiling by array of methamphetamine (METH)-treated rats with high or low behavioural responses against saline-treated controls
Released on 4 January 2007, last updated on 30 October 2015
To gain a better understanding of the mechanisms associated with the differences in the individual response to METH and thereby, further develop a list of candidate genes and pathways of possible relevance to human stimulant dependence, mania and psychosis, we conducted the present study. Rats were treated acutely with either METH or saline and their behavior measured for 3 hours after drug administration. METH treated rats were divided into high responders (HR) and low responders (LR) based on their stereotypy response. We compared gene expression between HR and LR and between these two groups and saline control.
transcription profiling by array, co-expression, compound treatment, stimulus or stress
Differential Regulation of Immediate-Early Gene Expression in the Prefrontal Cortex of Rats with a High vs Low Behavioral Response to Methamphetamine. Shilling PD, Kuczenski R, Segal DS, Barrett TB, Kelsoe JR. , Europe PMC 16855532