E-MEXP-839 - Transcription profiling of liver from wild type mice of different ages to determine whether gene expression changes in naturally aged mice overlap with those from DNA repair deficient mice

Status
Submitted on 17 August 2006, released on 21 December 2006, last updated on 27 March 2012
Organism
Mus musculus
Samples (16)
Array (1)
Protocols (5)
Description
To investigate whether and to which extent the gene expression changes in DNA repair deficient mice (i.e. Csbm/m/Xpa-/- and Ercc1-/-) overlap with those observed in a natural aged liver, we sought to compare the full mouse liver transcriptome of adult 16-, 96- and 130-week old wt C57Bl/6J mice (n=4) with that of adult 8-week old wt C57Bl/6J mice
Experiment types
transcription profiling by array, physiological process
Contacts
George A Garinis <g.garinis@erasmusmc.nl>, Gijsbertus van der Horst, Ingrid van der Pluijm
Citation
A new progeroid syndrome reveals that genotoxic stress suppresses the somatotroph axis. Laura J. Niedernhofer1, George A. Garinis, Anja Raams, Astrid S. Lalai, Andria Rasile Robinson, Esther Appeldoorn, Hanny Odijk, Roos Oostendorp, Anwaar Ahmad, Wibeke van Leeuwen, Arjan F. Theil, Wim Vermeulen, Gijsbertus T. J. van der Horst, Peter Meinecke, Wim J. Kleijer, Jan Vijg, Nicolaas G. J. Jaspers & Jan H. J. Hoeijmakers. Nature 444:1038-1043 (2006), Europe PMC 17183314
MIAME
PlatformsProtocolsFactorsProcessedRaw
Files
Investigation descriptionE-MEXP-839.idf.txt
Sample and data relationshipE-MEXP-839.sdrf.txt
Raw data (1)E-MEXP-839.raw.1.zip
Array designA-AFFY-45.adf.txt
Links