E-MEXP-772 - Transcription profiling of four mouse cell lines with mutations in the oncogenic tyrosine kinase gene BCR-Abl
Submitted on 5 July 2006, released on 1 August 2007, last updated on 2 May 2014
Gene expression profile variation between 4 BCR-Abl transduced cell lines:
1-Mouse DA1-3b cell line as reference,
2-DR1 imatinib resistant clone with E255K BCR-abl mutation
3-DRBMSR 2 dasatinib resistant clone with E255K and T315I BCR-Abl mutation.
4-DRBMSR 7 dasatinib resistant clone with E255K and T315I and V299L BCR-Abl mutation
BCR-ABL is an oncogenic tyrosine kinase involved in the development of chronic myelogenous leukaemia (CML).
transcription profiling by array, loop, strain or line