E-MEXP-562 - Transcription profiling of nude mice tumor biopsies generated by the injection of mesenchymal stem cells (MSC)
Submitted on 14 February 2006, released on 26 December 2006, last updated on 2 May 2014
Transformed MSC were injected subcutaneously into the flank of athymic CD1 nude mice (C/River). Biopsies of 1.5 cm spindle cell tumours were taken.
transcription profiling by array, disease state
Transformation of human mesenchymal stem cells increases their dependency on oxidative phosphorylation for energy production. Funes, Juan M.; Quintero, Marisol; Henderson, Stephen; Martinez, Dolores; Qureshi, Uzma; Westwood, Claire; Clements, Mark O.; Bourboulia, Dimitra; Pedley, R. Barbara; Moncada, Salvador; Boshoff, Chris. Proc Natl Acad Sci U S A 104(15):6223 (2007), Europe PMC 17384149