E-MEXP-3917 - Transcription profiling by array of cerebellum from dogs with demyelinating canine distemper virus encephalitis
Released on 23 April 2014, last updated on 3 May 2014
Canine distemper virus (CDV)-induced demyelinating leukoencephalitis (CDV-DL) in dogs is a translational animal model for human demyelinating diseases such as multiple sclerosis. The aim of this study was to perform an assumption-free microarray analysis of gene expression in different subgroups of CDV-DL as compared to normal controls. Dogs were classified into normal controls (group 1), acute CDV-DL lesions with CDV within the brain but without demyelination and inflammation (group 2), subacute lesions with demyelination but without inflammation (group 3), and subacute to chronic lesions with demyelination and inflammation (group 4).
transcription profiling by array, co-expression, disease state design, in vivo
Transcriptional changes in canine distemper virus-induced demyelinating leukoencephalitis favor a biphasic mode of demyelination. Ulrich Reiner, Puff Christina, Wewetzer Konstantin, Kalkuhl Arno, Deschl Ulrich, Baumgärtner Wolfgang. PLoS One 9:e95917 (2014)