E-MEXP-3917 - Transcription profiling by array of cerebellum from dogs with demyelinating canine distemper virus encephalitis

Status
Released on 23 April 2014, last updated on 3 May 2014
Organism
Canis familiaris
Samples (26)
Array (1)
Protocols (5)
Description
Canine distemper virus (CDV)-induced demyelinating leukoencephalitis (CDV-DL) in dogs is a translational animal model for human demyelinating diseases such as multiple sclerosis. The aim of this study was to perform an assumption-free microarray analysis of gene expression in different subgroups of CDV-DL as compared to normal controls. Dogs were classified into normal controls (group 1), acute CDV-DL lesions with CDV within the brain but without demyelination and inflammation (group 2), subacute lesions with demyelination but without inflammation (group 3), and subacute to chronic lesions with demyelination and inflammation (group 4).
Experiment types
transcription profiling by array, co-expression, disease state design, in vivo
Contact
Citation
Transcriptional changes in canine distemper virus-induced demyelinating leukoencephalitis favor a biphasic mode of demyelination. Ulrich Reiner, Puff Christina, Wewetzer Konstantin, Kalkuhl Arno, Deschl Ulrich, Baumgärtner Wolfgang. PLoS One 9:e95917 (2014)
MIAME
PlatformsProtocolsFactorsProcessedRaw
Files
Investigation descriptionE-MEXP-3917.idf.txt
Sample and data relationshipE-MEXP-3917.sdrf.txt
Raw data (1)E-MEXP-3917.raw.1.zip
Processed data (1)E-MEXP-3917.processed.1.zip
Array designA-AFFY-149.adf.txt
Links