E-MEXP-3851 - Transcription profiling by array of P. verticalis adult male livers exposed to municipal wastewater effluents to investigate genomic and phenotypic response
Released on 10 December 2013, last updated on 15 January 2015
Laboratory tests with marine flatfish were conducted to investigate associations among gene expression, higher biological responses and wastewater effluent exposure. Previous studies showed molecular responses such as elevated concentrations of plasma estradiol and vitellogenin in wild male hornyhead turbot (Pleuronichthys verticalis). In the present study, male hornyhead turbot were exposed to environmentally realistic (0.5%) and higher (5%) concentrations of chemically enhanced advanced-primary (PL) and full-secondary treated (HTP) effluents from two southern California wastewater treatment plants (WWTP). Hepatic gene expression was examined using a custom low-density microarray.
transcription profiling by array, co-expression, compound treatment, dose response, replicate
Genomic and phenotypic response of hornyhead turbot exposed to municipal wastewater effluents. Vidal-Dorsch DE, Bay SM, Ribecco C, Sprague LJ, Angert M, Ludka C, Ricciardelli E, Carnevali O, Greenstein DJ, Schlenk D, Kelley KM, Reyes JA, Snyder S, Vanderford B, Wiborg LC, Petschauer D, Sasik R, Baker M, Hardiman G. Aquatic Toxicology (2013), Europe PMC 23796538