E-MEXP-3764 - Transcription profiling by array of Pseudomonas aeruginosa treated with fosfomycin, tobramycin or a combination of both drugs under aerobic and anaerobic conditions

Status
Released on 28 August 2013, last updated on 3 May 2014
Organism
Pseudomonas aeruginosa
Samples (24)
Array (1)
Protocols (4)
Description
The experiment aimed to characterise the transcriptional response of a clinical CF P. aeruginosa isolate to sub-inhibitory concentrations of fosfomycin, tobramycin and a novel 4/1 (w/w) combination of the two (FT) under both aerobic and anaerobic conditions
Experiment types
transcription profiling by array, co-expression, compound treatment, in vitro
Contact
Citation
Fosfomycin and tobramycin in combination downregulate nitrate reductase genes narG and narH, resulting in increased activity against P. aeruginosa under anaerobic conditions.
MIAME
PlatformsProtocolsFactorsProcessedRaw
Files
Investigation descriptionE-MEXP-3764.idf.txt
Sample and data relationshipE-MEXP-3764.sdrf.txt
Raw data (1)E-MEXP-3764.raw.1.zip
Processed data (1)E-MEXP-3764.processed.1.zip
Array designA-AFFY-30.adf.txt
Links