E-MEXP-3764 - Transcription profiling by array of Pseudomonas aeruginosa treated with fosfomycin, tobramycin or a combination of both drugs under aerobic and anaerobic conditions
Released on 28 August 2013, last updated on 3 May 2014
The experiment aimed to characterise the transcriptional response of a clinical CF P. aeruginosa isolate to sub-inhibitory concentrations of fosfomycin, tobramycin and a novel 4/1 (w/w) combination of the two (FT) under both aerobic and anaerobic conditions
transcription profiling by array, co-expression, compound treatment, in vitro
Fosfomycin and tobramycin in combination downregulate nitrate reductase genes narG and narH, resulting in increased activity against P. aeruginosa under anaerobic conditions.