E-MEXP-3746 - Transcription profiling by array of human aortic endothelial cells after treatment with IFN-alpha in order to determine whether IFN-alpha can directly activate the endothelium
Released on 11 September 2013, last updated on 3 May 2014
Systemic Lupus Erythematosus is associated with an increased risk of cardiovascular disease (CVD). Interferon-response genes have been associated with endothelial dysfunction in SLE patients. The aim of this study is to identify the effects of IFN-alpha on human endothelial cells in order to determine whether IFN-alpha can directly activate the endothelium.
transcription profiling by array, co-expression, compound treatment, in vitro
The effect of type 1 IFN on human aortic endothelial cell function in vitro: relevance to systemic lupus erythematosus. Reynolds JA, Ray DW, Zeef LA, ONeill T, Bruce IN, Alexander MY. J Interferon Cytokine Res 34(5):404-412 (2014), Europe PMC 24444308