E-MEXP-3682 - Transcription profiling by array of siRNA silencing of GABPA in MCF10A cells
Released on 15 July 2013, last updated on 2 July 2014
The ETS transcription factor GABPA controls cell migration in breast epithelial cells through targeting a cohort of genes, independently from another family member ELK1, and thereby achieves biological specificity. Here, both direct and indirect target genes for GABPA are identified by siRNA silencing of GABPA. Therefore, although ELK1 and GABPA ultimately control the same biological process, they do so by regulating distinct cohorts of target genes associated with actin cytoskeletal functions and cell migration control.
transcription profiling by array, cellular modification, co-expression, in vivo
The ETS transcription factors ELK1 and GABPA regulate different gene networks to control MCF10A breast epithelial cell migration. Odrowaz Z, Sharrocks AD. PLoS One 7(12):e49892 (2012), Europe PMC 23284628