E-MEXP-3640 - Transcription profiling by array of cancerous and non-cancerous human prostate cell lines treated with PY-ITC or sulforaphane in the presence and absence of the PI3K inhibitor LY294002
Last updated on 23 April 2013, released on 24 April 2013
Non cancerous PNT1A and cancerous PC3 prostate cells were treated with a novel isothiocyanate (PY-ITC) and compared to sulforaphane (SF), an isothiocyanate (ITC) derived from broccoli. Treatments with these ITCs were performed in the presence and absence on the PI3K inhibitor LY294002.
transcription profiling by array, cell type comparison, co-expression, compound treatment, in vitro
Enhanced in Vitro Biological Activity of Synthetic 2-(2-Pyridyl) Ethyl Isothiocyanate Compared to Natural 4-(Methylsulfinyl) Butyl Isothiocyanate. Melchini A, Needs PW, Mithen RF, Traka MH. Journal of Medicinal Chemistry 55(22):9682–9692 (2012), Europe PMC 22998472