E-MEXP-3591 - Transcriptional profiling by array of human monocytes to study their involement in HIV-Tuberculosis associated Immune Reconstitution Inflammatory Syndrome at week 2 of combined antiretroviral threapy
Last updated on 26 February 2013, released on 8 July 2013
Tuberculosis-associated Immune Reconstitution Inflammatory Syndrome (TB-IRIS) is a common complication in HIV-TB coinfected patients receiving combined antiretroviral therapy (cART). While monocytes/macrophages play major roles in both HIV- and TB-infection individually, a putative contribution of monocytes to the development of TB-IRIS remains unexamined. To investigate the possible functional contribution of monocytes to TB-IRIS pathogenesis, one of our first steps was to apply a genome-wide microarray analysis in monocytes of HIV-TB co-infected patients shortly after cART initiation. Based on the coparison of gene profiles between the TB-IRIS group and the control group, the modulated genes and pathways will be further investigated.
transcription profiling by array, co-expression, disease state, ex vivo
Modulations of the Complement System in Peripheral Blood Monocytes Contribute to Tuberculosis-associated Immune Reconstitution Inflammatory Syndrome (TB-IRIS).