E-MEXP-3490 - Transcription profiling by array of mouse embrynoic hearts of Numbl knockout and wild type
Released on 17 January 2013, last updated on 16 October 2015
The ventricular wall of the heart is composed of trabeculated and compactlayers, which are separated by yet unknown processes during embryonic development. Notch signaling plays important roles in cardiac development. Mutations in Notch signaling components are related to human congenital heart diseases Two homologues, Numb and Numblike (Numbl), are expressed in mammals, which also act as inhibitors of Notch signaling Here we investigate the role of Notch2 and Numb/Numblike during myocardial trabeculation and compaction. The aim of the experiment is to analyze whether Numb/Numblike are involved in inhibition of Notch activity in the developing heart.
transcription profiling by array, co-expression, genetic modification, in vivo
Inhibition of Notch2 by Numb/Numblike controls myocardial compaction in the heart. Yang J, Bucker S, Jungblut B, Bottger T, Cinnamon Y, Tchorz J, Müller M, Bettler B, Harvey R, Sun QY, Schneider A, Braun T. , Europe PMC 22865640