E-MEXP-3469 - Role of JunD in macrophage activation under LPS stimulation
Released on 1 April 2013, last updated on 3 June 2014
To investigate the effects of the differences seen in the JUND binding patterns between WKY and WKY.LCrgn2 bone marrow derieved macrophages, we have 1) analysed gene expression changes over a time course (4 time points 0,2,4 and8 hrs) of stimulation with lipopolysaccharide (LPS) using whole transcript expression microarrays. 2) We also knocked JunD in WKY for the first and the last time points.
transcription profiling by array, co-expression, compound treatment, genetic modification, in vitro, reference, time series
JunD/AP1 regulatory network analysis during macrophage activation in a rat model of crescentic glomerulonephritis. Srivastava PK, Hull RP, Behmoaras J, Petretto E, Aitman TJ. BMC Systems Biology 7(1):93 (2013)
Combined ChIP-Seq and transcriptome analysis identifies AP-1/JunD as a primary regulator of oxidative stress and IL-1β synthesis in macrophages. Hull RP, Srivastava PK, DSouza Z, Atanur SS, Mechta-Grigoriou F, Game L, Petretto E, Cook HT, Aitman TJ, Behmoaras J. BMC Genomics 14:92 (2013), Europe PMC 23398888