E-MEXP-3393 - Transcription profiling by array of rat cardiac myocytes exposed to endothelin-1 for 30 or 90 min
Released on 1 October 2012, last updated on 19 October 2015
Cardiac myocytes were exposed to 100 nM endothelin-1 for 30 or 90 min to determine effects on mRNA expression using Exon arrays
transcription profiling by array, co-expression, compound treatment, replicate
Feedback regulation by Atf3 in the endothelin-1-responsive transcriptome of cardiomyocytes: Egr1 is a principal Atf3 target. Giraldo A, Barrett OP, Tindall MJ, Fuller SJ, Amirak E, Bhattacharya BS, Sugden PH, Clerk A. , Europe PMC 22390138
p90 ribosomal S6 kinases play a significant role in early gene regulation in the cardiomyocyte response to G(q)-protein-coupled receptor stimuli, endothelin-1 and α(1)-adrenergic receptor agonists. Amirak E, Fuller SJ, Sugden PH, Clerk A.