E-MEXP-3311 - MicroRNA profiling by array of mouse dendritic cells during spontaneous and LPS-induced maturation
Released on 4 November 2013, last updated on 2 May 2014
We identify a panel of microRNAs that are differentially expressed during both spontaneous and LPS-induced DC maturation and show the M-CSF receptor (M-CSFR) as a key target for microRNA-mediated regulation. MicroRNA-22, -34a and -155 are up-regulated in mature GM-CSF-generated DC and mediate M-CSFR mRNA and protein down-regulation.
transcription profiling by array, cellular process, co-expression, in vitro
MicroRNA-mediated down-regulation of M-CSF receptor contributes to maturation of mouse monocyte-derived dendritic cells. Riepsaame J, van Oudenaren A, den Broeder BJH, van IJcken WFJ, Pothof J and Leenen PJM. Front. Immunol. 4:353 (2013)