E-MEXP-3311 - MicroRNA profiling by array of mouse dendritic cells during spontaneous and LPS-induced maturation

Status
Released on 4 November 2013, last updated on 2 May 2014
Organism
Mus musculus
Samples (12)
Array (1)
Protocols (7)
Description
We identify a panel of microRNAs that are differentially expressed during both spontaneous and LPS-induced DC maturation and show the M-CSF receptor (M-CSFR) as a key target for microRNA-mediated regulation. MicroRNA-22, -34a and -155 are up-regulated in mature GM-CSF-generated DC and mediate M-CSFR mRNA and protein down-regulation.
Experiment types
transcription profiling by array, cellular process, co-expression, in vitro
Contact
Citation
MicroRNA-mediated down-regulation of M-CSF receptor contributes to maturation of mouse monocyte-derived dendritic cells. Riepsaame J, van Oudenaren A, den Broeder BJH, van IJcken WFJ, Pothof J and Leenen PJM. Front. Immunol. 4:353 (2013)
MIAME
PlatformsProtocolsFactorsProcessedRaw
Files
Investigation descriptionE-MEXP-3311.idf.txt
Sample and data relationshipE-MEXP-3311.sdrf.txt
Raw data (1)E-MEXP-3311.raw.1.zip
Processed data (2)E-MEXP-3311.processed.1.zip, E-MEXP-3311.processed.2.zip
Array designA-MEXP-2085.adf.txt
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