E-MEXP-3032 - Response of Streptomyces coelicolor to treatment with the antibiotics vancomycin bacitracin and moenomycin A
Released on 29 April 2011, last updated on 18 January 2015
Streptomyces coelicolor A3(2)
To determine the response at the transcriptional level of S. coelicolor cells to treatment with 3 antibiotics that target distinct stages of cell wall biosynthesis, biological triplicate cultures of strain M600 were treated with sub-lethal concentrations (10 µg/ml) of vancomycin, bacitracin or moenomycin A. Samples were taken 0, 30, 60, 90 minutes after addition of the antibiotic. A negative control which received no drug treatment was also performed.
transcription profiling by array, co-expression, in vivo, stimulus or stress, time series
Genome-wide dynamics of a bacterial response to antibiotics that target the cell envelope. Hesketh, A., Hill, C., Mokhtar, J., Novotna, G., Bibb, M., and Hong, H.-J. BMC Genomics 12:226 (2011), Europe PMC 21569315