E-MEXP-2514 - Transcription profiling by array of Rattus norvegicus kidneys from strains with different salt sensitivities in the context of hypertension, with and without salt treatment
Last updated on 27 October 2012, released on 27 October 2012
Compare effects of salt in salt sensitive, salt resistant and congenic rat strains. There were 6 groups of animals: SHRSP salt-loaded, SHRSP, SP.WKYGla2a salt-loaded, SP.WKYGla2a, WKY salt-loaded, WKY, , The salt loaded animals had 1% salt added to their drinking water at 18 weeks of age. Non treated animals were not supplied with salt. All animals were sacrificed, by overdose of anaesthetic and exsaguination, at 21 weeks of age and tissues snap frozen in liquid N2. Tissues were removed to -70 degrees C for storage.
transcription profiling by array, co-expression, disease state, ex vivo, genetic modification, replicate, strain or line
Predictive response-relevant clustering of expression data provides insights into disease processes. Hopcroft LE, McBride MW, Harris KJ, Sampson AK, McClure JD, Graham D, Young G, Holyoake TL, Girolami MA, Dominiczak AF. Nucleic Acids Res 38(20):6831-6840 (2010), Europe PMC 20571087