E-MEXP-199 - Transcription profiling of response of human Hep3B (Hepatoma cells) following rAdTAp63 or rAdTAp53 transfer
Submitted on 16 October 2004, released on 1 June 2005, last updated on 2 May 2014
We performed microarray analyses to examine whether TAp63alpha is able to induce the expression of several pro-apoptotic and immunosystem related genes in Hep3B (hepatoma) cells. We investigated the downstream mechanisms by which TAp53 elicits apoptosis.
transcription profiling by array, development or differentiation, time series
TAp63alpha induces apoptosis by activating signaling via death receptors and mitochondria. Gressner O, Schilling T, Lorenz K, Schulze Schleithoff E, Koch A, Schulze-Bergkamen H, Lena AM, Candi E, Terrinoni A, Catani MV, Oren M, Melino G, Krammer PH, Stremmel W, Müller M. EMBO J 24(13):2458-2471 (2005), Europe PMC 15944736