E-MEXP-1690 - Transcription profiling by array of human gangliogliomas and adjacent tissue
Released on 3 October 2008, last updated on 16 October 2015
Gangliogliomas, the most frequent neoplasms in patients with pharmacoresistant focal epilepsies, are characterized by histological combinations of glial and dysplastic neuronal elements, a highly differentiated phenotype and rare gene mutations.
Here, we have used discrete microdissected ganglioglioma and adjacent control brain tissue obtained from the neurosurgical access to the tumour of identical patients (n = 6) carefully matched for equivalent glial and neuronal elements in an amount sufficient for oligonucleotide microarray hybridization without repetitive amplification. Multivariate statistical analysis identified a rich profile of genes with altered expression in gangliogliomas.
transcription profiling by array, all pairs, co-expression, disease state
Array analysis of epilepsy-associated gangliogliomas reveals expression patterns related to aberrant development of neuronal precursors. Fassunke, Jana; Majores, Michael; Tresch, Achim; Niehusmann, Pitt; Grote, Alexander; Schoch, Susanne; Becker, Albert J.