E-GEOD-97 - Transcription profiling of 91 human and mouse samples across a diverse array of tissues, organs, and cell lines to provide a preliminary, but substantial, description of the normal mammalian transcriptome.
Released on 19 December 2007, last updated on 12 October 2011
High-throughput gene expression profiling has become an important tool for investigating transcriptional activity in a variety of biological samples. To date, the vast majority of these experiments have focused on specific biological processes and perturbations. Here, we have generated and analyzed gene expression from a set of samples spanning a broad range of biological conditions. Specifically, we profiled gene expression from 91 human and mouse samples across a diverse array of tissues, organs, and cell lines. Because these samples predominantly come from the normal physiological state in the human and mouse, this dataset represents a preliminary, but substantial, description of the normal mammalian transcriptome. We have used this dataset to illustrate methods of mining these data, and to reveal insights into molecular and physiological gene function, mechanisms of transcriptional regulation, disease etiology, and comparative genomics. Finally, to allow the scientific community to use this resource, we have built a free and publicly accessible website (http://expression.gnf.org) that integrates data visualization and curation of current gene annotations.
transcription profiling by array, co-expression, organism part comparison
Large-scale analysis of the human and mouse transcriptomes. Andrew I. Su, Michael P. Cooke, Keith A. Ching, Yaron Hakak, John R. Walker, Tim Wiltshire, Anthony P. Orth, Raquel G. Vega, Lisa M. Sapinoso, Aziz Moqrich, Ardem Patapoutian, Garret M. Hampton, Peter G. Schultz*, and John B. Hogenesch.