E-GEOD-8738 - Array-CGH screening of pediatric T-lymphoblastic leukemias (n=73)

Status
Released on 25 August 2007, last updated on 2 May 2014
Organism
Homo sapiens
Samples (146)
Array (1)
Protocols (7)
Description
DNA copy-number profiling of 73 T-ALLs Keywords: Genetic modification Comparison of tumor DNA (tumor) versus control DNA (pool of lymphocyte DNA from 10 healthy donors). Whole-genome screening for DNA copy-number aberrations using array-based comparative genomic hybridization (aCGH). Tumor DNA labeled in Cy3 and control DNA labeled in Cy5.
Experiment type
comparative genomic hybridization by array 
Contacts
Stefan M Pfister <s.pfister@dkfz.de>, Andreas Kulozik, Bernhard Radlwimmer, Grischa Toedt, Marc Remke, Peter Lichter, Stefan Pfister, Wiebke Werft
Citation
High-resolution genomic profiling of childhood T-ALL reveals frequent copy-number alterations affecting the TGF-beta and PI3K-AKT pathways and deletions at 6q15-16.1 as a genomic marker for unfavorable early treatment response. Remke M, Pfister S, Kox C, Toedt G, Becker N, Benner A, Werft W, Breit S, Liu S, Engel F, Wittmann A, Zimmermann M, Stanulla M, Schrappe M, Ludwig WD, Bartram CR, Radlwimmer B, Muckenthaler MU, Lichter P, Kulozik AE. , Europe PMC 19406988
MIAME
PlatformsProtocolsFactorsProcessedRaw
Files
Investigation descriptionE-GEOD-8738.idf.txt
Sample and data relationshipE-GEOD-8738.sdrf.txt
Raw data (1)E-GEOD-8738.raw.1.zip
Processed data (1)E-GEOD-8738.processed.1.zip
Array designA-GEOD-5713.adf.txt
R ExpressionSetE-GEOD-8738.eSet.r
Links