E-GEOD-8679 - Transcription profiling of mouse white adipose tissue
Submitted on 3 August 2007, released on 16 June 2008, last updated on 27 March 2012
Trans-10, Cis-12 conjugated linoleic acid (t10c12 CLA) causes fat loss in mouse white adipose tissue (WAT). The early transcriptome changes in WAT were analyzed using high-density microarrays to better characterize the signaling pathways responding to t10c12 CLA. Their gene expression responses between 4 to 24 hr after treatment showed a common set of early gene expression changes indicative of an integrated stress response (ISR). Experiment Overall Design: Mouse WAT RNA for each time point was isolated from two control and two treatment samples for analysis on four microarrays. The two control and two treatment samples consisted of RP tissues from 5 pooled mice for each sample, requiring a total of twenty mice for the four samples taken at each time point.
transcription profiling by array, unknown experiment type
Trans-10, cis-12 conjugated linoleic acid activates the integrated stress response pathway in adipocytes. P Christopher LaRosa, Jean-Jack M Riethoven, Han Chen, Yuannan Xia, You Zhou, Mei Chen, Jess Miner, Michael E Fromm. Physiol Genomics 31(3):544-53 (2007)