E-GEOD-8644 - Differentially expressed genes among motor and prefrontal areas of macaque monkey neocortex
Released on 31 August 2007, last updated on 27 March 2012
Motor-related areas of neocortex are highly differentiated into several subareas from both functional and cytoarchitectural aspects in the higher primates. To assess the molecular basis of such areal specialization, we investigated the gene expression profiles of primary motor area (M1), premotor area (dorsal and ventral) (PMd and PMv) and prefrontal area (A46) in the rhesus monkey by DNA microarray method. We found that 476 genes were differentially expressed among those areas. More than half of those genes were most abundantly expressed in M1, and most genes were complementarily expressed between M1 and A46. The expression profiles of PMd and PMv were similar to each other compared to those of M1 and A46. The data will give us a fundamental basis for further analysis of structure-function relationship of the primate brain. Keywords: cerebral neocortex; rhesus monkey; primary motor area; premotor area; prefrontal area Twenty four brain tissues from 4 areas (M1, PMd, PMv and A46) of right and left hemispheres of 3 adolescent rhesus monkeys (Macaca mulatta) aged 2.6-2.7 years which had been bred in group cages without any experimental treatments. Adequate measures were taken to minimize pain and discomfort, in accordance with the National Institute of Health Guide for the Care and Use of Laboratory Animals (NIH publication no. 80-23).
transcription profiling by array
Toshio Kojima <firstname.lastname@example.org>, Akira Sato, Fumiharu Tsuboi, Hirotaka Onoe, Kimika Saito, Masahito Takahashi, Noriyuki Higo, Tadashi Isa, Takao Oishi, Toshio Kojima, Yukio Nishimura, Yumi Murata
Differentially expressed genes among motor and prefrontal areas of macaque neocortex. Sato A, Nishimura Y, Oishi T, Higo N, Murata Y, Onoe H, Saito K, Tsuboi F, Takahashi M, Isa T, Kojima T. , Europe PMC 17761142