E-GEOD-8401 - Transcription profiling of human melanoma xenotransplant metastatis model - gene signature for aggression of melanoma metastases

Status
Submitted on 6 July 2007, released on 16 June 2008, last updated on 10 June 2011
Organism
Homo sapiens
Samples (83)
Array (1)
Protocols (6)
Description
Metastasis is the deadliest phase of cancer progression. Experimental models using immunodeficient mice have been used to gain insights into the mechanisms of metastasis. We report here the identification of a “metastasis aggressiveness gene expression signature” derived using human melanoma cells selected based on their metastatic potentials in a xenotransplant metastasis model. Comparison with expression data from human melanoma patients shows that this metastasis gene signature correlates with the aggressiveness of melanoma metastases in human patients. Many genes encoding secreted and membrane proteins are included in the signature, suggesting the importance of tumor-microenvironment interactions during metastasis. Experiment Overall Design: test signature genereated from experiments of parental cell line vs xenograft model
Experiment types
transcription profiling by array, unknown experiment type
Contact
MIAME
PlatformsProtocolsFactorsProcessedRaw
Files
Investigation descriptionE-GEOD-8401.idf.txt
Sample and data relationshipE-GEOD-8401.sdrf.txt
Raw data (2)E-GEOD-8401.raw.1.zip, E-GEOD-8401.raw.2.zip
Processed data (1)E-GEOD-8401.processed.1.zip
Array designA-AFFY-33.adf.txt
R ExpressionSetE-GEOD-8401.eSet.r
Links