E-GEOD-769 - Transcription profiling of pancreases of cystic fibrosis mouse with a genotype of gastrin+/-, CFTR-/- to study the gene expression patterns in cystic fibrosis.
Submitted on 22 October 2003, released on 15 December 2007, last updated on 27 March 2012
Total RNA was prepared using TRIzol reagent from the pancreata of eight week old male mice. The genotypes were Control: gastrin+/-, CFTR+/+; and CF: gastrin+/-, CFTR-/-. All mice were on 95% black6, 5% 129Sv background. Mice were fed Peptamen from age 10 days to prevent intestinal obstruction.
transcription profiling by array, co-expression, disease state, individual genetic characteristics
Acidic duodenal pH alters gene expression in the cystic fibrosis mouse pancreas. Simran Kaur, Oxana Norkina, Donna Ziemer, Linda C Samuelson, Robert C De Lisle. Am J Physiol Gastrointest Liver Physiol 287(2):G480-90 (2004)