E-GEOD-7384 - Transcription profiling of mouse Dnmt3L+/- sires compared to offspring of Dnmt3L+/+ sires to investigate the effect of paternal haploinsufficiency for Dnmt3L

Status
Submitted on 27 March 2007, released on 15 June 2008, last updated on 2 May 2014
Organism
Mus musculus
Samples (4)
Array (1)
Protocols (5)
Description
There is increasing evidence that epigenetic information can be inherited across generations in mammals, despite extensive reprogramming both in the gametes and the early developing embryo. One corollary to this is that disruption of the establishment of epigenetic state in the gametes of a parent, as a result of heterozygosity for mutations in genes involved in reprogramming, could affect the phenotype of offspring that do not inherit the mutant allele. Here we show that such effects do occur following paternal inheritance in the mouse. We detect changes to transcription and chromosome ploidy in adult animals. Paternal effects of this type have not been reported previously in mammals and suggest that the untransmitted genotype of male parents can influence the phenotype of their offspring. Experiment Overall Design: Offspring of Dnmt3L+/- sires compared to offspring of Dnmt3L+/+ sires
Experiment types
transcription profiling by array, unknown experiment type
Contact
Russell Leigh McInnes
Citation
Modifiers of epigenetic reprogramming show paternal effects in the mouse. Suyinn Chong, Nicola Vickaryous, Alyson Ashe, Natasha Zamudio, Neil Youngson, Sarah Hemley, Tomas Stopka, Arthur Skoultchi, Jacqui Matthews, Hamish S Scott, David de Kretser, Moira O'Bryan, Marnie Blewitt, Emma Whitelaw. Nat Genet 39(5):614-22 (2007)
MIAME
PlatformsProtocolsFactorsProcessedRaw
Files
Investigation descriptionE-GEOD-7384.idf.txt
Sample and data relationshipE-GEOD-7384.sdrf.txt
Processed data (1)E-GEOD-7384.processed.1.zip
Array designA-AGIL-21.adf.txt
Links