E-GEOD-7091 - Transcription profiling of mouse liver to identify hepatic genes differentially expressed in the presence of the maslinic acid in olive oil
Submitted on 21 February 2007, released on 25 January 2009, last updated on 27 March 2012
Two olive oils only differing in the presence of maslinic acid were prepared. Using DNA microarrays, hepatic gene expression was analysed in apoE-deficient mice with a C57BL/6J genetic background Experiment Overall Design: The experimental animals were 12, two-month old, female, homozygous apoE KO mice with a C57BL/6J genetic background. Experiment Overall Design: Two study groups were established: a) one received a chow diet (Teklad Mouse/Rat Diet no. 2014, Harlan Teklad, Harlan Ibérica, Barcelona, Spain) supplemented with 10% (w/w) olive oil (diet OO) (n=6), and b) the other received the same chow diet but supplemented with 10% (w/w) maslinic acid- enriched olive oil (diet MAOO; n= 6 and).
transcription profiling by array, unknown experiment type
Apolipoprotein E determines the hepatic transcriptional profile of dietary maslinic acid in mice. Acín Guillen, Arnal Surra, García-Granados Godino, Ruiz-Gutiérrez Muniesa, Osada.