E-GEOD-6681 - Transcription profiling of mouse Foxp3 ablation in peripheral mature regulatory T cells
Submitted on 8 January 2007, released on 15 June 2008, last updated on 27 March 2012
Analysis of Foxp3 ablated peripheral regulatory T cells. Regulatory T cells require the expression of the transcription factor Foxp3 for thymic development. It is not known whether continuous expression of Foxp3 is required for the maintained function of mature regulatory T cells in the periphery. Results indicate changes to the regulatory T cell developmental program in the absence of Foxp3. Experiment Overall Design: Compare Cre recombinase treated peripheral regulatory T cells possessing a Cre sensitive Foxp3 locus to Cre treated regulatory T cells with a wild type Foxp3 locus. Cre exposure is observed via the Cre sensitive expression of the yellow flourescent protein molecule.
transcription profiling by array, unknown experiment type
Maintenance of the Foxp3-dependent developmental program in mature regulatory T cells requires continued expression of Foxp3. Luke M Williams, Alexander Y Rudensky. Nat Immunol 8(3):277-84 (2007)