E-GEOD-6681 - Transcription profiling of mouse Foxp3 ablation in peripheral mature regulatory T cells

Status
Submitted on 8 January 2007, released on 15 June 2008, last updated on 27 March 2012
Organism
Mus musculus
Samples (4)
Array (1)
Protocols (4)
Description
Analysis of Foxp3 ablated peripheral regulatory T cells. Regulatory T cells require the expression of the transcription factor Foxp3 for thymic development. It is not known whether continuous expression of Foxp3 is required for the maintained function of mature regulatory T cells in the periphery. Results indicate changes to the regulatory T cell developmental program in the absence of Foxp3. Experiment Overall Design: Compare Cre recombinase treated peripheral regulatory T cells possessing a Cre sensitive Foxp3 locus to Cre treated regulatory T cells with a wild type Foxp3 locus. Cre exposure is observed via the Cre sensitive expression of the yellow flourescent protein molecule.
Experiment types
transcription profiling by array, unknown experiment type
Contact
Alexander Rudensky
Citation
MIAME
PlatformsProtocolsFactorsProcessedRaw
Files
Investigation descriptionE-GEOD-6681.idf.txt
Sample and data relationshipE-GEOD-6681.sdrf.txt
Raw data (1)E-GEOD-6681.raw.1.zip
Processed data (1)E-GEOD-6681.processed.1.zip
Array designA-AFFY-45.adf.txt
R ExpressionSetE-GEOD-6681.eSet.r
Links