E-GEOD-6348 - Expression data of skeletal muscle from HRT users and non-users

Status
Released on 12 November 2007, last updated on 13 May 2014
Organism
Homo sapiens
Samples (30)
Array (1)
Protocols (35)
Description
Modification of Gene Expression of Skeletal Muscle in Response to postmenopause with or without Hormone Replacement Therapy. Even though menopause is often accompanied with first signs of age-associated changes in muscle structure and function, the effects of hormone replacement therapy (HRT) or menopause-related decline in estrogen production in the muscles of postmenopausal women is not well understood. We have used a randomized double-blinded study design together with an explorative microarray experiment to characterize possible effects of continuous, combined HRT and estrogen deprivation on the skeletal muscle of fifteen early postmenopausal women from which 10 used HRT and 5 used placebo for 12-months in a douple-blinded design. Keywords: time course analysis from HRT users and non-users comparison of gene expression in skeletal muscle of healthy postmenopausel women using HRT (n=10) vs not-using HRT (n=5)
Experiment type
transcription profiling by array 
Contacts
Eija Pöllänen <eija.pollanen@jyu.fi>, Harri Suominen, Jukka Puolakka, Paula Ronkainen, Sarianna Sipilä, Satu Koskinen, Timo Takala, Vuokko Kovanen
Citation
Muscular transcriptome in postmenopausal women with or without hormone replacement. P�ll�nen E, Ronkainen PH, Suominen H, Takala T, Koskinen S, Puolakka J, Sipil� S, Kovanen V. , Europe PMC 17985945
MIAME
PlatformsProtocolsVariablesProcessedRaw
Files
Investigation descriptionE-GEOD-6348.idf.txt
Sample and data relationshipE-GEOD-6348.sdrf.txt
Processed data (1)E-GEOD-6348.processed.1.zip
Array designA-MEXP-525.adf.txt
Links