E-GEOD-59888 - Epigenetic activation of neuronal gene expression by JMJD3 is required for postnatal and adult brain neurogenesis

Status
Released on 30 July 2014, last updated on 2 August 2014
Organism
Mus musculus
Samples (9)
Array (1)
Protocols (6)
Description
The epigenetic mechanisms that enable lifelong neurogenesis from neural stem cells (NSCs) in the adult mammalian brain are poorly understood. Here we show that JMJD3, a histone H3-lysine 27 (H3K27) demethylase, acts as a critical activator of neurogenesis. 3 biological replicates of JMJD3 null (P9 UBC-Cre/ERT2;Jmjd3F/F) and 3 biological replicates of littermate controls were used to analyze the effect of JMJD3 deletion on gene expression.
Experiment type
transcription profiling by array 
Contacts
Siyuan John Liu <John.Liu@ucsf.edu>, Dae H Park, Daniel A Lim, Siyuan J Liu
MIAME
PlatformsProtocolsVariablesProcessedRaw
Files
Investigation descriptionE-GEOD-59888.idf.txt
Sample and data relationshipE-GEOD-59888.sdrf.txt
Processed data (1)E-GEOD-59888.processed.1.zip
Additional data (1)E-GEOD-59888.additional.1.zip
Array designA-MEXP-1174.adf.txt
Links