E-GEOD-59888 - Epigenetic activation of neuronal gene expression by JMJD3 is required for postnatal and adult brain neurogenesis
Released on 30 July 2014, last updated on 2 August 2014
The epigenetic mechanisms that enable lifelong neurogenesis from neural stem cells (NSCs) in the adult mammalian brain are poorly understood. Here we show that JMJD3, a histone H3-lysine 27 (H3K27) demethylase, acts as a critical activator of neurogenesis. 3 biological replicates of JMJD3 null (P9 UBC-Cre/ERT2;Jmjd3F/F) and 3 biological replicates of littermate controls were used to analyze the effect of JMJD3 deletion on gene expression.
transcription profiling by array
Siyuan John Liu <John.Liu@ucsf.edu>, Dae H Park, Daniel A Lim, Siyuan J Liu