E-GEOD-56965 - Gene expression profiling of wild type and CCR2-/- mice post chikungunya infection

Status
Released on 23 April 2014, last updated on 28 April 2014
Organism
Mus musculus
Samples (4)
Arrays (2)
Protocols (6)
Description
A number of inhibitors of chemokine CCL2 and its receptor CCR2 are in development and may find application for treating a range of inflammatory conditions, including autoimmune and viral arthritides. Herein we sought to determine the effect of CCR2 deficiency on arthritis caused by an arthritogenic alphavirus, Chikungunya virus. Chikungunya virus (LR2006-OPY1) was injected subcutaneously into the hind foot of either CCR2 knockout or wild-type control mice (n=4-6). At day 0 and d7 post infection, RNA from the feet was harvested, the RNA was pooled (4-6 feet per time point per mouse strain) and gene expression analysis was performed using Mouse Gene ST arrays (Affymetrix).
Experiment type
transcription profiling by array 
Contacts
Helder I Nakaya <hnakaya@emory.edu>, Andreas Suhrbier, Helder Nakaya, Joy Gardner, Lee D Major, Thibaut Larcher, Thuy T Le, Wayne A Schroder, Yee S Poo
MIAME
PlatformsProtocolsFactorsProcessedRaw
Files
Investigation descriptionE-GEOD-56965.idf.txt
Sample and data relationshipE-GEOD-56965.sdrf.txt
Raw data (1)E-GEOD-56965.raw.1.zip
Processed data (1)E-GEOD-56965.processed.1.zip
Array designsA-AFFY-130.adf.txt, A-GEOD-16570.adf.txt
Links