E-GEOD-56112 - Expression Array analysis of MTAP in HT080 cells
Released on 30 April 2014, last updated on 3 June 2014
Methylthioadenosine Phosphorylase (MTAP) is a tumor suppressor gene that encodes an enzyme responsible for the catabolism of the polyamine byproduct 5′deoxy-5′-methylthioadenosine (MTA). To elucidate the mechanism by which MTAP inhibits tumor formation, we have created isogenic MTAP+ and MTAP- HT1080 fibrosarcoma cells. In this experiment we have performed expression array analysis on MTAP-, MTAP+, and MTAP+ cells treated with the MTAP inhibitor MT-DADMe-ImmA. Three biological replicates of each sample were grown and analyzed. M- is MTAP-. M+ is MTAP+, and M+I is MTAP treated with inhibitor (48 hours).
transcription profiling by array
warren kruger <firstname.lastname@example.org>, Baiqing Tan, Michael Slifker, Warren Kruger, Yue-Sheng Li