E-GEOD-5496 - Transcription profiling of livers from mice overexpress ABCA1 in LDL receptor -/- genetic background to characterize the effects of ABCA1 overexpression.

Status
Submitted on 10 August 2006, released on 13 November 2007, last updated on 27 March 2012
Organism
Mus musculus
Samples (8)
Array (1)
Protocols (6)
Description
Changes in the transcript profile due to ABCA1 expression in murine liver samples was evaluated in LDL receptor -/- genetic backgrounds. Experiment Overall Design: Case (ABCA1-transgenic) versus control (wild-type) design with 4 biological replicates per condition
Experiment types
transcription profiling by array, co-expression, individual genetic characteristics
Contact
Eric Billings
Citation
ABCA1 overexpression in the liver of LDLr-KO mice leads to accumulation of pro-atherogenic lipoproteins and enhanced atherosclerosis. Charles W Joyce, Elke M Wagner, Federica Basso, Marcelo J Amar, Lita A Freeman, Robert D Shamburek, Catherine L Knapper, Jafri Syed, Justina Wu, Boris L Vaisman, Jamila Fruchart-Najib, Eric M Billings, Beverly Paigen, Alan T Remaley, Silvia Santamarina-Fojo, H Bryan Brewer. J Biol Chem 281(44):33053-65 (2006)
MIAME
PlatformsProtocolsFactorsProcessedRaw
Files
Investigation descriptionE-GEOD-5496.idf.txt
Sample and data relationshipE-GEOD-5496.sdrf.txt
Raw data (1)E-GEOD-5496.raw.1.zip
Processed data (1)E-GEOD-5496.processed.1.zip
Array designA-AFFY-36.adf.txt
R ExpressionSetE-GEOD-5496.eSet.r
Links