E-GEOD-5496 - Transcription profiling of livers from mice overexpress ABCA1 in LDL receptor -/- genetic background to characterize the effects of ABCA1 overexpression.
Submitted on 10 August 2006, released on 13 November 2007, last updated on 27 March 2012
Changes in the transcript profile due to ABCA1 expression in murine liver samples was evaluated in LDL receptor -/- genetic backgrounds. Experiment Overall Design: Case (ABCA1-transgenic) versus control (wild-type) design with 4 biological replicates per condition
transcription profiling by array, co-expression, individual genetic characteristics
ABCA1 overexpression in the liver of LDLr-KO mice leads to accumulation of pro-atherogenic lipoproteins and enhanced atherosclerosis. Charles W Joyce, Elke M Wagner, Federica Basso, Marcelo J Amar, Lita A Freeman, Robert D Shamburek, Catherine L Knapper, Jafri Syed, Justina Wu, Boris L Vaisman, Jamila Fruchart-Najib, Eric M Billings, Beverly Paigen, Alan T Remaley, Silvia Santamarina-Fojo, H Bryan Brewer. J Biol Chem 281(44):33053-65 (2006)