E-GEOD-5462 - Transcription profiling of human sequential breast cancer biopsies during letrozole treatment
Released on 13 June 2008, last updated on 12 October 2011
In the present investigation, we have exploited the opportunity provided by neoadjuvant treatment of a group of postmenopausal women with large operable or locally advanced breast cancer (in which therapy is given with the primary tumour remaining within the breast) to take sequential biopsies of the same cancers before and after 10-14 days treatment with letrozole. RNA extracted from the biopsies has been subjected to Affymetrix microarray analysis and the data from paired biopsies interrogated to discover genes whose expression is most influenced by oestrogen deprivation. Experiment Overall Design: biopsies were taken from the same subjects both pretreatment and after 10-14 days Letrozol, 2.5 mg/day, oral
transcription profiling by array, unknown experiment type
Changes in breast cancer transcriptional profiles after treatment with the aromatase inhibitor, letrozole. William R Miller, Alexey A Larionov, Lorna Renshaw, Thomas J Anderson, Sharon White, Juliette Murray, Emma Murray, Garret Hampton, John R Walker, Steven Ho, Andreas Krause, Dean B Evans, John Michael Dixon.