E-GEOD-5388 - Transcription profiling of human brain tissue from subjects with bipolar disorder and healthy controls
Submitted on 25 July 2006, released on 24 June 2007, last updated on 27 March 2012
Bipolar affective disorder is a severe psychiatric disorder with a strong genetic component but unknown pathophysiology. We used microarray technology (Affymetrix HG-U133A GeneChips) to determine the expression of approximately 22 000 mRNA transcripts in post-mortem brain tissue (dorsolateral prefrontal cortex) from patients with bipolar disorder and matched healthy controls. A cohort of 70 subjects was investigated and the final analysis included 30 bipolar and 31 control subjects. Differences between disease and control groups were identified using a rigorous statistical analysis with correction for confounding variables and multiple testing.
transcription profiling by array, co-expression, disease state
Gene expression analysis of bipolar disorder reveals downregulation of the ubiquitin cycle and alterations in synaptic genes. M M Ryan, H E Lockstone, S J Huffaker, M T Wayland, M J Webster, S Bahn. Mol Psychiatry 11(10):965-78 (2006)