E-GEOD-52735 - Gene signature predictive of response to chemotherapy in mCRC [array]
Released on 1 December 2013, last updated on 3 June 2014
The objective is to generate a robust and validated predictor profile for chemotherapy response in patients with mCRC using microarray gene expression profiles of primary colorectal cancer tissue. To define a gene signature of response to chemotherapy in metastatic colorectal cancer, samples were obtained from 40 patients from Marques de Valdecilla Hospital who underwent primary surgery. Gene expression was detected and quantified using the Human Whole Genome U133 Plus 2.0 array (Affymetrix), containing 54675 human gene probes. Adequate RNA and microarray analysis were obtained from only 37 patients.
transcription profiling by array
Amancio Carnero, Fernando Rivero, Javier Gomez, Luis Paz-Ares, Maria D Pastor, Marta Benavent-Viñuales, Purificacion Estevez-Garcia, Rocio Garcia-Carbonero, Sonia Molina-Pinelo