E-GEOD-52563 - Genome-wide analysis of serum starved prelamin A-accumulating hMSCs gene expression.

Status
Released on 23 June 2014, last updated on 28 June 2014
Organism
Homo sapiens
Samples (6)
Array (1)
Protocols (12)
Description
Analysis of serum starved prelamin A-accumulating hMSCs at gene expression level. The hypothesis tested in the present study was that prelamin A accumulation induces the dysregulation of genes that are essensial for cell survival under a stress condition such as serum starvation. The results provide important information about these genes and the functional categories that are dysregulated due to prelamin A accumulation in serum starved hMSCs. Two samples are analyzed in this microarray experiment: human mesenchymal stem cell cultured under serum starvation conditions (during 24 hours) which accumulate prelamin A (pre-hMSCs) and control mesenchymal stem cells (ctrl-hMSCs). 2 biological replicates (hMSCs derived from 2 different bone marrow donors) and 1 technical replicate are included in this analysis.
Experiment type
transcription profiling by array 
Contacts
Clara Isabel Rodriguez <geo@ncbi.nlm.nih.gov>, Andrea Gago, Arantza Infante, Clara I Rodríguez, Garbiñe Ruiz de Eguino
Citation
Prelamin A accumulation and stress conditions induce impaired Oct-1 activity and autophagy in prematurely aged human mesenchymal stem cell. Infante A, Gago A, de Eguino GR, Calvo-Fern�ndez T, G�mez-Vallejo V, Llop J, Schlangen K, Fullaondo A, Aransay AM, Mart�n A, Rodr�guez CI.
MIAME
PlatformsProtocolsFactorsProcessedRaw
Files
Investigation descriptionE-GEOD-52563.idf.txt
Sample and data relationshipE-GEOD-52563.sdrf.txt
Processed data (1)E-GEOD-52563.processed.1.zip
Array designA-GEOD-10558.adf.txt
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