E-GEOD-52563 - Genome-wide analysis of serum starved prelamin A-accumulating hMSCs gene expression.
Released on 23 June 2014, last updated on 28 June 2014
Analysis of serum starved prelamin A-accumulating hMSCs at gene expression level. The hypothesis tested in the present study was that prelamin A accumulation induces the dysregulation of genes that are essensial for cell survival under a stress condition such as serum starvation. The results provide important information about these genes and the functional categories that are dysregulated due to prelamin A accumulation in serum starved hMSCs. Two samples are analyzed in this microarray experiment: human mesenchymal stem cell cultured under serum starvation conditions (during 24 hours) which accumulate prelamin A (pre-hMSCs) and control mesenchymal stem cells (ctrl-hMSCs). 2 biological replicates (hMSCs derived from 2 different bone marrow donors) and 1 technical replicate are included in this analysis.
transcription profiling by array
Clara Isabel Rodriguez <email@example.com>, Andrea Gago, Arantza Infante, Clara I Rodríguez, Garbiñe Ruiz de Eguino
Prelamin A accumulation and stress conditions induce impaired Oct-1 activity and autophagy in prematurely aged human mesenchymal stem cell. Infante A, Gago A, de Eguino GR, Calvo-Fernï¿½ndez T, Gï¿½mez-Vallejo V, Llop J, Schlangen K, Fullaondo A, Aransay AM, Martï¿½n A, Rodrï¿½guez CI.