E-GEOD-51905 - Expression data from differentiated 3T3-L1 pre-adipocytes.
Released on 4 April 2014, last updated on 3 June 2014
Stearoyl-CoA desaturase (SCD) is the rate-limiting enzyme catalyzing the conversion of saturated fatty acids palmitate and stearate to monounsaturated fatty acids palmitoleate and oleate. During adipocyte differentiation, SCD expression increases concomitantly with several transcription factors and lipogenic genes. We used microarrays to examine gene expression in differentiated pre-adipocytes treated with and without an SCD inhibitor. On day 7 of adipocyte differentiation, total RNA was extracted from adipocytes. Two conditions were selected for comparison: total RNA extracted from adipocytes treated with DMSO (control) and or a SCD inhibitor.
transcription profiling by array
David M Mutch <email@example.com>, Flavia Badoud
Inhibition of stearoyl-CoA desaturase-1 in differentiating 3T3-L1 preadipocytes upregulates elongase 6 and downregulates genes affecting triacylglycerol synthesis. Ralston JC, Badoud F, Cattrysse B, McNicholas PD, Mutch DM. , Europe PMC 24566853