E-GEOD-51774 - Changes in the expression of miR-381 and miR-495 are inversely associated with the expression of the MDR1 gene and development of multi-drug resistance

Status
Released on 29 October 2013, last updated on 25 November 2013
Organism
Homo sapiens
Samples (2)
Protocols (4)
Description
Multidrug resistance (MDR) frequently develops in cancer patients exposed to chemotherapeutic agents and is usually brought about by over-expression of P-glycoprotein (P-gp) which acts as a drug efflux pump. MiRNAome profiling using next-generation sequencing identified differentially expressed microRNAs (miRs) between parental K562 cells and MDR K562 cells (K562/ADM) induced by chronic adriamycin treatment. MiRNAome profiling in untreated K562 cells and K562 cells exposed to long-term adriamycin treatment
Experiment type
RNA-seq of non coding RNA 
Contacts
Stephen John Ohms <Stephen.Ohms@anu.edu.au>, Guangming Gong, Jun Y Fan, M F Shannon, Qiao Wang, Stephen J Ohms, Yan Xu, Yiqiao Hu, Zhen Li, Zhiyong Mao
MINSEQE
Exp. designProtocolsFactorsProcessedSeq. reads
Files
Investigation descriptionE-GEOD-51774.idf.txt
Sample and data relationshipE-GEOD-51774.sdrf.txt
Links