E-GEOD-51739 - Anticancer properties of distinct antimalaria drug classes
Released on 26 October 2013, last updated on 3 June 2014
Background: Antimalarials have anticancer potential. Results: We have systematically tested five distinct antimalaria drugs in a panel of cancer cell lines. Conclusion: Three antimalarial classes display potent antiproliferative activity, and their potency is correlated with cancer cell gene expression patterns. Significance: We confirm and extend anticancer potential of these antimalarials and we discuss their therapeutic potential based on clinical data. Key words: Malaria, Anticancer drug, Drug Discovery, Genomics, Gene Expression, Bioinformatics, Cancer Affymetrix® HG-U133 Plus 2.0 mRNA expression arrays were used to determine the expression. CEL result files were pre-processed using the RMA (Irizarry et al, 2003) algorithm. This microarray analysis was performed for 91 cell lines.
transcription profiling by array
Jaga Virayah <Jaga.Virayah@oncotest.de>, Gerhard Kelter, Ingmar Peitz, Jonathan Vennerstrom, Kelly Chibale, Kip Guy, Margaret A Phillips, Richard Haynes, Rob Hooft van Huijsduijnen, Timothy N Wells, Yongyuth Yuthavong