E-GEOD-51725 - EGFR expression status associated with lymph node ratio

Status
Released on 26 October 2013, last updated on 13 May 2014
Organism
Homo sapiens
Samples (10)
Array (1)
Protocols (6)
Description
We have tried to identify molecules associated with lymph node ratio expression by microarray. Expression microarray data prioritized gene candidates according to average expression ratio and its frequency. Among these genes, we examined particular EGFR expression by immunohistochemistry (IHC) in 167 advanced gastric cancer. We compared tumor specimens with high LNR (n=4) with those with low one (n=4) at mRNA level by Affymetrix microarray (harboring 54,675 genes) in stage III gastric cancer. We then prioritized the expression data, and enriched genes correlated with LNR, and finally validated EGFR as such candidates in primary advanced gastric cancer who underwent standard treatment (n=167).
Experiment type
transcription profiling by array 
Contacts
Akira Ema <akiema@med.kitasato-u.ac.jp>, Hirosuke Kobayashi, Keika Hoshi, Keishi Yamashita, Kenichi Kokubo, Mina Waraya, Yoshiko Shinkai
MIAME
PlatformsProtocolsFactorsProcessedRaw
Files
Investigation descriptionE-GEOD-51725.idf.txt
Sample and data relationshipE-GEOD-51725.sdrf.txt
Raw data (1)E-GEOD-51725.raw.1.zip
Processed data (1)E-GEOD-51725.processed.1.zip
Array designA-AFFY-44.adf.txt
Links