E-GEOD-51388 - Intra-MZ pair discordance and longitudinal variation of whole-genome scale DNA methylation in adults

Status
Released on 30 October 2013, last updated on 4 November 2013
Organism
Homo sapiens
Samples (60)
Array (1)
Protocols (7)
Description
In this study, we used Illumina Infinium HumanMethylation450 Beadchips to compare DNA methylation profiles in blood from 10 pairs of MZ twins and 8 individuals recruited at 0, 3, 6, and 9 months. MZ Group (Group A) contained 10 pairs of MZ twins ranging from 23 to 74 years old, including 8 female and 12 male subjects.Longitudinal study group (Group B) included a pair of MZ (male) twins and 6 unrelated individuals (3 male, 3 female), aged from 24 to 39. Except subject H, all participants in Longitudinal study group (Group B) were recalled every 3 months for 9 months (0, 3, 6, and 9 m). Subject H was studied only at 0, 6, and 9 months. Bisulphite converted DNA from the 60 samples were hybridised to the Illumina Infinium 450k Human Methylation Beadchip
Experiment type
methylation profiling by array 
Contacts
Na Zhang <zngoluk@hotmail.com>, Chengtao Li, Daru Lu, Jingzhong Chen, Min Shen, Shumin Zhao, Su-Hua Zhang
MIAME
PlatformsProtocolsVariablesProcessedRaw
Files
Investigation descriptionE-GEOD-51388.idf.txt
Sample and data relationshipE-GEOD-51388.sdrf.txt
Processed data (2)E-GEOD-51388.processed.1.zip, E-GEOD-51388.processed.2.zip
Additional data (1)E-GEOD-51388.additional.1.zip
Array designA-GEOD-13534.adf.txt
Links