E-GEOD-51099 - Expression data from Ctla4-/- and DKO CD4+ Tconv cells
Status | Released on 25 September 2013, last updated on 30 September 2013 | ||||||||||
Organism | Mus musculus | ||||||||||
Samples (4) | |||||||||||
Array (1) | |||||||||||
Protocols (6) | |||||||||||
Description | Ctla4-/- mice suffer from a severe autoimmunity characterized by indiscriminate self-reactive T cell activation. Itk-/-Ctla4-/- (DKO) mice are protected from lethal autoimmunity despite a fulminant autoimmune process in the LNs as self-reative T cells fail to migrate to destroy tissues. We used microarray to identify underlying differences in gene expression that could account for lack of migration of DKO T cells into tissues. CD4+CD25neg T cells from 3 weeks old male Ctla4-/- or DKO mice were sorted in duplicates, RNA was extracted using TRIzol reagent and microarray analysis performed with the Affymetrix MoGene 1.0 ST array | ||||||||||
Experiment type | transcription profiling by array | ||||||||||
Contacts | Joonsoo Kang <joonsoo.kang@umassmed.edu>, Nitya Jain | ||||||||||
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