E-GEOD-5078 - Transcription profiling of C57BL/6NIA mouse hippocampus to survey age-related changes in mRNA levels.

Status
Submitted on 14 June 2006, released on 27 November 2007, last updated on 27 March 2012
Organism
Mus musculus
Samples (23)
Array (1)
Protocols (6)
Description
We carried out a global survey of age-related changes in mRNA levels in the C57BL/6NIA mouse hippocampus and found a difference in the hippocampal gene expression profile between 2-month-old young mice and 15-month-old middle-aged mice correlated with an age-related cognitive deficit in hippocampal-based explicit memory formation. Middle-aged mice displayed a mild but specific deficit in spatial memory in the Morris water maze. Experiment Overall Design: No technical replicates; 14 biological replicates for 15-month-old mice, 9 biological replicates for 2-month-old mice. Whole hippocampus.
Experiment types
transcription profiling by array, co-expression, time series
Contact
Citation
Altered hippocampal transcript profile accompanies an age-related spatial memory deficit in mice. Miguel Verbitsky, Amanda L Yonan, Gaël Malleret, Eric R Kandel, T Conrad Gilliam, Paul Pavlidis. Learn Mem 11(3):253-60
MIAME
PlatformsProtocolsFactorsProcessedRaw
Files
Investigation descriptionE-GEOD-5078.idf.txt
Sample and data relationshipE-GEOD-5078.sdrf.txt
Processed data (1)E-GEOD-5078.processed.1.zip
Array designA-AFFY-6.adf.txt
Links