E-GEOD-49165 - Expression data from mesenchymal stem cells of ossifying fibroma

Status
Released on 24 July 2013, last updated on 3 June 2014
Organism
Homo sapiens
Samples (3)
Array (1)
Protocols (7)
Description
Ossifying fibroma (OF) is a common benign fibro-osseous neoplasm of orofacial bones, showing progressive enlargement of the affected jaw with deficiency in bone formation. Our aim is to discover the molecular difference between mesenchymal stem cells from OF and normal jaw bone to provide basis for development of clinical therapy. Global gene expression comparison and gene ontology analysis found that several singaling pathways are involved in the process, including TGFb signaling and Notch signaling. Inhibition of TGFb signaling in mesenchymal stem cells of OF can increase the osteogenesis and decrease proliferation, shedding light on developing strategies for therapy. RNA from mesenchymal stem cells of OF is compared to that of normal jaw bone.
Experiment type
transcription profiling by array 
Contacts
Cunye Qu, Songtao Shi
MIAME
PlatformsProtocolsFactorsProcessedRaw
Files
Investigation descriptionE-GEOD-49165.idf.txt
Sample and data relationshipE-GEOD-49165.sdrf.txt
Raw data (1)E-GEOD-49165.raw.1.zip
Processed data (1)E-GEOD-49165.processed.1.zip
Array designA-AFFY-37.adf.txt
Links