E-GEOD-48057 - Effects of Citalopram Exposure on Osteogenesis in Mouse Calvarial Pre-Osteoblasts

Status
Released on 19 June 2013, last updated on 24 June 2013
Organism
Mus musculus
Samples (4)
Array (1)
Protocols (7)
Description
Recently, serotonin and serotonin reuptake inhibitor (SSRI) drugs have been shown to have an effect on the development and maintenance of bone. However, little is known about its role in craniofacial development. We used microarray as one tool to determine the gene expression profile of intramembranous (calvarial) derived murine pre-osteoblasts after citalopram (SSRI) exposure. We isolated whole RNA from MC3T3-E1 cells treated with proliferation media or proliferation media with SSRI at a dose of 10^-4 mol./liter for 3 or 7 days in culture. We then used an Affymetrix array and compared expression profiles between control and experimental treatments.
Experiment type
transcription profiling by array 
Contacts
MIAME
PlatformsProtocolsVariablesProcessedRaw
Files
Investigation descriptionE-GEOD-48057.idf.txt
Sample and data relationshipE-GEOD-48057.sdrf.txt
Raw data (1)E-GEOD-48057.raw.1.zip
Processed data (1)E-GEOD-48057.processed.1.zip
Array designA-AFFY-130.adf.txt
Links